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Home Antibody All anti-PRDM1 antibodies

Anti-PRDM1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319145
  • Rabbit polyclonal PRDM1 BLIMP1 antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400479) , 20ug
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenThis affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the C-terminus of human, mouse, and rat PRDM1/BLIMP1.
Clone Name IsotypeIgG
Species Reactivityhuman, mouse, rat, dog Concentration1.15 mg/mL
Guaranteed Application *WB Suggested DilutionsELISA: 1:65,000 - 1:80,000, WB: 1:1,000, IP: 5-10 ug/mL
Buffer0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Note PRDM1/Blimp1 (PR domain zinc finger protein 1, PR domain-containing protein 1, Beta-interferon gene positive regulatory domain I-binding factor, BLIMP-1, Positive regulatory domain I-binding factor 1, PRDI-binding factor 1, or PRDI-BF1, or Beta-lymphocyte-induced maturation protein 1) is one of several transcription factors which drives the maturation of B-lymphocytes into Ig secreting cells. In the nucleus, PRDM1/BLIMP1 functions as a transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Transcription of the PRDM1 gene is increased upon virus induction. PRDM1/Blimp1 also interacts with PRMT5. Two alternatively spliced transcript variants that encode different isoforms have been reported.

Reference Data

Target NameHomo sapiens PR domain containing 1, with ZNF domain (PRDM1), transcript variant 1
Alternative NameBLIMP1; PRDI-BF1
Database LinkNP_001189
Function
Related Pathway

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WB Image
Western blots using affinity purified anti-PRDM1/BLIMP1 antibody show detection of overexpressed PRDM1/BLIMP1 in whole transfected Raji cell lysate (lane 2) at ~88kDa. Lane 1 shows mock transfection in whole Raji cell lysate. Detection of endogenous PRDM1/BLIMP1 (lane 4) is illustrated in human plasma cell nuclear extract, but not in Raji whole cell nuclear extract (lane 3). The identity of the lower dark band at ~50-60kDa is unknown. Primary antibody was used at a 1:1000 dilution in 5% PBS-Tween. Personal communication, Hyesuk Yoon and Jerry Boss, Emory University, Atlanta, GA

 

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