Home Antibody All anti-PPP3CB antibodies
Also for PPP3CB (NM_021132)
|Synthetic peptide corresponding to residues surrounding amino acids 267 of human Calcineurin A|
|Human, mouse, rat, hamster, rabbit, bovine
||WB: 1-4ug/ml, IP: 10-20ug/ml
|100 µg (0.2 mg/ml) affinity purified, rabbit anti-Calcineurin A polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Homo sapiens protein phosphatase 3, catalytic subunit, beta isozyme (PPP3CB), transcript variant 2|
|CALNA2; CALNB; CNA2; PP2Bbeta|
Entrez Gene 5532 Human
Entrez Gene 19056 Mouse
Entrez Gene 24675 Rat
|Calcineurin is a calcium/calmodulin-dependent serine/threonine protein phosphatase. The active enzyme is a heterodimer consisting of a catalytic A subunit of 61 kDa and a myristylated regulatory B subunit of 19 kDa that binds calcium. The catalytic A subunit consists of an amino terminal catalytic domain, followed by calmodulin and B subunit binding sites, and a caboxyl-terminal autoinhibitory domain. Calnineurin is the target of immunosuppressant drugs such as cyclosporin A and FK506. Calcineurin controls the translocation of nuclear factors of activated T cells (NFAT), a family of transcriptional activators that control the expression of cytokine genes essential to immune response, from the cytosol into the nucleus of activated T cells. Calcineurin has been proposed to play an important role in mediating calcium-activated cell death.|
|PhosphataseTranscription FactorsDruggable Genome MAPK signaling pathwayCalcium signaling pathwayOocyte meiosisApoptosisWnt signaling pathwayAxon guidanceMore Pathways >> |
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Western blot analysis of Calcineurin A in lysate from Jurkat cells (Lane 1) and rat kidney (Lane 2).