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Home Antibody All anti-POU5F1 antibodies

Anti-POU5F1 Antibody EPR2053(2)


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against Oct-4A(clone EPR2053(2))
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400950) , 20ug Explanation
100ul $325 3-7 Days
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Also for POU5F1 (NM_002701)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the N-terminus of human Oct-4A was used as an immunogen.
Clone NameEPR2053(2) IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; FC: 1:10 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for ICC or IHC-P.

Reference Data

Target NameHomo sapiens POU class 5 homeobox 1 (POU5F1), transcript variant 1
Alternative NameOct-3; Oct-4; OCT3; OCT4; OTF-3; OTF3; OTF4
Database LinkNP_002692
Entrez Gene 5460 Human
FunctionOctamer transcription factor-4 (Oct-4) is a homeodomain transcription factor in the POU transcription factor family that specifically binds to the octamer motif (5’-ATTTCAT-3’) (1). It is critical for early embryogenesis and for embryonic stem cell pluripotency, expressed mainly in the developing brain (1). Oct-4 is a master regulator that affects the fate of pluripotent stem cells and germ cell precursors (2). For instance, the downregulation of Oct-4 triggers embryonic stem cell differentiation, simultaneous with gastrulation (3). It is also used as a marker for germ cell tumor diagnosis (4). Oct-4 exists as two different isoforms, Oct-4A and Oct-4B. Oct-4A can sustain embryonic stem cell self-renewal, whereas Oct-4B is localized in the cytoplasm (5).
Related PathwayStem cell - PluripotencyAdult stem cellsCancer stem cellsEmbryonic stem cellsInduced pluripotent stem cellsTranscription Factors

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Oct4 antibody [EPR2053(2)]; All lanes : Anti-Oct4 antibody [EPR2053(2)] at 1/1000 dilution.Lane 1 : Human seminoma lysate.Lane 2 : NCCIT cell lysate.Lysates/proteins at 10 ug per lane.Performed under reducing conditions.Predicted band size : 39 kDa.


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