Homo sapiens POU class 5 homeobox 1 (POU5F1), transcript variant 1
Synonyms:
Oct-3; Oct-4; OCT3; OCT4; OTF-3; OTF3; OTF4
Immunogen
A synthetic peptide corresponding to residues in the N-terminus of human Oct-4A was used as an immunogen.
Buffer
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Octamer transcription factor-4 (Oct-4) is a homeodomain transcription factor in the POU transcription factor family that specifically binds to the octamer motif (5’-ATTTCAT-3’) (1). It is critical for early embryogenesis and for embryonic stem cell pluripotency, expressed mainly in the developing brain (1). Oct-4 is a master regulator that affects the fate of pluripotent stem cells and germ cell precursors (2). For instance, the downregulation of Oct-4 triggers embryonic stem cell differentiation, simultaneous with gastrulation (3). It is also used as a marker for germ cell tumor diagnosis (4). Oct-4 exists as two different isoforms, Oct-4A and Oct-4B. Oct-4A can sustain embryonic stem cell self-renewal, whereas Oct-4B is localized in the cytoplasm (5).
Related Pathway
Wnt Signaling Pathway
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