The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq].
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PON1 (RC210356, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PON1.
HEK293T cells transfected with either RC210356 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-PON1 antibody(TA502612), and then analyzed by flow cytometry.
Flow cytometric Analysis of Jurkat cells, using anti-PON1 antibody(TA502612),(Red), compared to a nonspecific negative control antibody(TA50011),(Blue).
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