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Anti-PLCG1 PHOSPHO Antibody EPR2610Y
Also for PLCG1 (NM_002660)
|A phospho specific peptide corresponding to residues surrounding tyrosine 771 of human PLC?1 was used as an immunogen. This antibody detects PLC?1 phosphorylated on tyrosine 771.|
||0.5~1.0 mg/ml (Lot Dependent)
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens phospholipase C, gamma 1 (PLCG1), transcript variant 1|
|NCKAP3; PLC-II; PLC1; PLC148; PLCgamma1|
|The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |
EGFR1 Signaling Pathway
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Western blot - Phospholipase C gamma 1 (phospho Y771) antibody [EPR2610Y]; All lanes : Anti-Phospholipase C gamma 1 (phospho Y771) antibody [EPR2610Y] at 1/20000 dilution.Lane 1 : Jurkat cell lysate (without pervanadate).Lane 2 : Jurkat cell lysate treated with pervanadate.Lysates/proteins at 10 µg per lane.Secondary.HRP conjugated Goat anti-Rabbit at 1/2000 dilution.Predicted band size : 149 kDa.Observed band size : ~155 kDa .