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Anti-PLCG1 PHOSPHO Antibody EP1898Y
Also for PLCG1 (NM_002660)
|A phospho-specific peptide corresponding to residues surrounding Tyrosine 783 was used as an immungen. This antibody detects PLC ? I phosphorylated at Y783.|
||Tissue culture supernatant
||Lot dependent; please refer to CoA along with shipment
||WB: 1:100000 - 1:200000; ICC: 1:250 - 1:500
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens phospholipase C, gamma 1 (PLCG1), transcript variant 1|
|NCKAP3; PLC-II; PLC1; PLC148; PLCgamma1|
|The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |
EGFR1 Signaling Pathway
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Western blot - Phospholipase C gamma 1 (phospho Y783) antibody [EP1898Y]; All lanes : Anti-Phospholipase C gamma 1 (phospho Y783) antibody [EP1898Y] at 1/200000 dilution.Lane 1 : Jurkat cell lysates, untreated.Lane 2 : Jurkat cell lysates, treated with pervanadate.Lysates/proteins at 10 µg per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 149 kDa.Observed band size : 149 kDa.