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Anti-PKN1 Antibody EPR3238


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against PKN1(clone EPR3238)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419135) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human PKN1 was used as an immunogen.
Clone NameEPR3238 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, FC Suggested DilutionsWB: 1:1000 - 1:10000; FC: 1:10 - 1:100
Predicted MW Explanation 104 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens protein kinase N1 (PKN1), transcript variant 2
Alternative NameDBK; PAK-1; PAK1; PKN; PKN-ALPHA; PRK1; PRKCL1
Database LinkNP_002732
Entrez Gene 5585 Human
Entrez Gene 320795 Mouse
Entrez Gene 29355 Rat
FunctionProtein kinase N (PKN) is a fatty acid- and Rho-activated serine/threonine protein kinase involved in the regulation of cell motility by association with cytoskeletal components such as neurofilament and alpha-actinin (1). Serine/threonine-protein kinase N1 (PKN1) belongs to the protein kinase C superfamily. It is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The phosphorylation of PKN1 by PDK1 may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis (2).
Related PathwayProtein KinaseDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - PKN antibody [EPR3238]; All lanes : Anti-PKN antibody [EPR3238] at 1/1000 dilution.Lane 1 : SH-SY-5Y cell lysates.Lane 2 : U937 cell lysates.Lane 3 : Jurkat cell lysates.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 104 kDa.Observed band size : 120 kDa .
Flow Cytometry - PKN antibody [EPR3238]; Flow cytometric analysis of PKN in permeabilized Jurkat cells, using a 1/10 dilution of TA307411 (red) or a rabbit IgG (negative) (green).


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