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Home Antibody All anti-PIK3R1 antibodies

Anti-PIK3R1 PHOSPHO Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA325781
  • Rabbit Polyclonal PI3-kinase p85- alpha/ gamma (Tyr467/199) Antibody (Phospho-specific)
100ul 325 In Stock
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WB(1)
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Also for PIK3R1 (NM_001242466)
cDNA Clone shRNA/siRNA Primer Pair Protein Request Antibody

OriGene Data

ImmunogenThe antiserum was produced against A synthesized peptide derived from human PI3-kinase p85- alpha/ gamma around the phosphorylation site of Tyrosine 467/199
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1
Guaranteed Application *WB Suggested DilutionsWB: 1:500-1:2000; IF/ICC: 1:100-1:500
Predicted MW Explanation 54,83kDa
BufferRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.

Reference Data

Target NameHomo sapiens phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1), transcript variant 4
Alternative NameAGM7; GRB1; IMD36; p85; p85-ALPHA
Database LinkNP_001229395
Entrez Gene 5295 Human
Entrez Gene 18708 Mouse
Entrez Gene 25513 Rat
FunctionPIK3R1 is a regulatory subunit of phosphoinositide-3-kinase. Mediates binding to a subset of tyrosine-phosphorylated proteins through its SH2 domain. Acts as an adapter, mediating the association of the p110 catalytic unit of the alpha, beta and delta enzymes to the plasma membrane, where p110 phosphorylates inositol lipids. May play an additional role in the regulation of the actin cytoskeleton. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
Related PathwayDruggable Genome ErbB signaling pathwayChemokine signaling pathwayPhosphatidylinositol signaling systemmTOR signaling pathwayApoptosisVEGF signaling pathwayMore Pathways >>

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WB Image
Western blot analysis of PI3-kinase p85- alpha/ gamma phosphorylation expression in H2O2 treated COS7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

 

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