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Home Antibody All anti-PIK3R1 antibodies

Anti-PIK3R1 Antibody ep380y


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SKU Description Amount Price Availability*  
TA300597 Rabbit Monoclonal Antibody against PIK3R1 (Clone EP380Y) 100ul $325 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the C-term of human PI3-K 85 alpha was used as an immunogen.
Clone Nameep380y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsIHC-P: Use at an assay dependent dilution; ICC/IF: 1:250 - 1:500; WB: 1:1000 - 1:2000; FC: 1:60; IP: 1:50
Predicted MW Explanation 85 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1), transcript variant 1
Alternative NameAGM7; GRB1; IMD36; p85; p85-ALPHA
Database LinkNP_852664
Entrez Gene 5295 Human
Entrez Gene 18708 Mouse
Entrez Gene 25513 Rat
FunctionPI3-Kinases (PI3-Ks) are a family of lipid kinases that are implicated in signal transduction. PI3-K consists of two subunits; the regulatory subunit p85 and the catalytic subunit p110 (1-2). In quiescent cells p85 maintains p110 in a low activity state. Upon growth factor stimulation, p85 directly interacts with phosphotyrosine residues of activated growth factor receptors or adaptor proteins leading to activation of p110. p85 exists in two isoforms: p85 , including two short forms termed p50 and p55/AS53 and p85 including short form p55 PIK/p55 (3). The p85 adaptor protein uses the inter-SH2 (iSH2) region to bind p110 and employs SH3 and SH2 domains, phosphotyrosine residues, and proline-rich motifs to interact with activated tyrosine kinases such as BCR/ABL and NPM/ALK or adaptor proteins including Shc, c-Cbl, Crk-L, and Gab2 (4-5).
Related PathwayDruggable Genome ErbB signaling pathwayChemokine signaling pathwayPhosphatidylinositol signaling systemmTOR signaling pathwayApoptosisVEGF signaling pathwayMore Pathways >>

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - PI 3 Kinase p85 alpha antibody [ep380y]; All lanes : Anti-PI 3 Kinase p85 alpha antibody [ep380y] at 1/2000 dilution.Lane 1 : A431 cells.Lane 2 : MCF-7 cells.Lane 3 : Raji cells.Lysates/proteins at 10 ug per lane.Predicted band size : 85 kDa.Observed band size : 85 kDa.

IHC Image
Immunohistochemistry (Paraffin-embedded sections) - PI 3 Kinase p85 alpha antibody [ep380y]; Staining of PI 3 Kinase p85 alpha on paraffin-embedded human breast carcinoma, using TA300597 diluted 1:100

IF Image
Immunofluorescence - PI 3 Kinase p85 alpha antibody [ep380y]; Immunofluorescent staining of PI 3 Kinase p85 alpha on HeLa cells using TA300597 diluted 1:250


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