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Anti-PIK3CD Antibody EPR386
Also for PIK3CD (NM_005026)
|A synthetic peptide corresponding to residues in human PI3-kinase subunit delta was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; ICC: 1:100 - 1:250
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta (PIK3CD)|
|APDS; IMD14; p110D; P110DELTA; PI3K|
Entrez Gene 5293 Human
Entrez Gene 18707 Mouse
Entrez Gene 366508 Rat
|Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that are implicated in signal transduction. PI3Ks consists of two subunits; p85 and p10. The p85 subunit localize PI3Ks activity to the plasma membrane while the p110 subunit contains the catalytic domain of PI3Ks (1-2). Four isoforms of p110 has been found; the alpha, beta, gamma, and delta subunit (3). The delta isoform is predominantly expressed in leukocytes and has been shown to interact with p85 and GTP-bound Ras via its SH2/SH3 domain (4).|
EGFR1 Signaling Pathway
Jak-STAT signaling pathway
Toll-like receptor signaling pathway
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Western blot - PI 3 Kinase p110 delta antibody [EPR386]; All lanes : Anti-PI 3 Kinase p110 delta antibody [EPR386] at 1/1000 dilution.Lane 1 : Jurkat cell lysate .Lane 2 : Raji cell lysate.Lane 3 : K562 cell lysate.Lane 4 : RAW 264.7 cell lysate.Lane 5 : Rat brain tissue lysate.Lane 6 : Rat kidney tissue lysate.Lane 7 : Rat spleen tissue lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 119 kDa.