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Home Antibody All anti-PIK3CA antibodies

Anti-PIK3CA Antibody EP383Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300605
  • Rabbit Monoclonal Antibody against PIK3CA (Clone EP383Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC416797) , 20ug
100ul 325 In Stock
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WB(1)
IF(1)
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Also for PIK3CA (NM_006218)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenA synthetic peptide of human near the C-term of PI3-K p110 alpha was used as an immunogen.
Clone NameEP383Y IsotypeTissue culture supernatant
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:1000 - 1:10000; ICC/IF: 1:100 - 1:250; IP: 1:30
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt or IHC.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt or IHC.

Reference Data

Target NameHomo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA)
Alternative NameCLOVE; CWS5; MCAP; MCM; MCMTC; p110-alpha; PI3K
Database LinkNP_006209
FunctionPI3-Kinases (PI3-Ks) are a family of lipid kinases that are implicated in signal transduction. PI3-K consists of two subunits; p85 and p10. The p85 subunit localize PI3-K activity to the plasma membrane while the p110 subunit contains the catalytic domain of PI3-K (1-2). Four isoforms of p110 has been found; ?, ?, ?, and the ? subunit. The alpha isoform, also known as PI3KCA, is a transforming oncogene (3) that was shown to have activating mutations in nine types of cancers such as colon, brain, breast and stomach (4-5). Three hot spot mutations (E542K and E545K; and H1047R) make p110? a potential drug target.
Related Pathway
EGFR1 Signaling Pathway
Focal Adhesion
Hemostasis
Jak-STAT signaling pathway
Signaling by GPCR
Toll-like receptor signaling pathway

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WB Image
Western blot - PI 3 Kinase catalytic subunit alpha antibody [EP383Y]; Anti-PI 3 Kinase catalytic subunit alpha antibody [EP383Y] at 1/5000 dilution + Jurkat cell lysate at 10 µg.Predicted band size : 110 kDa.Observed band size : 110 kDa.
IF Image
Immunocytochemistry/ Immunofluorescence - PI 3 Kinase catalytic subunit alpha antibody [EP383Y]; TA300605 staining HeLa cells (1:100 dilution).

 

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