Anti-PIK3C2B Antibody, Clone 3B1

Also for PIK3C2B (NM_002646)

OriGene Data

Immunogen	Full length human recombinant protein of human PIK3C2B(NP_002637) produced in HEK293T cell.
Clone Name	Clone 3B1	Isotype	IgG1
Species Reactivity	Human	Concentration	0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB 1:1000, IHC 1:150,
Buffer	PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification	Purified from mouse ascites fluids by affinity chromatography (Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta (PIK3C2B)
Alternative Name	C2-PI3K
Database Link	NP_002637
Function	The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008].
Related Pathway	EGFR1 Signaling Pathway

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WB Image

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PIK3C2B (RC218354, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PIK3C2B.

IHC Image

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-PIK3C2B mouse monoclonal antibody. (TA506052)

IHC Image

Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-PIK3C2B mouse monoclonal antibody. (TA506052)

IHC Image

Immunohistochemical staining of paraffin-embedded Human liver tissue using anti-PIK3C2B mouse monoclonal antibody. (TA506052)

IHC Image

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-PIK3C2B mouse monoclonal antibody. (TA506052)

IHC Image

Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-PIK3C2B mouse monoclonal antibody. (TA506052)

IHC Image

Immunohistochemical staining of paraffin-embedded Human endometrium tissue using anti-PIK3C2B mouse monoclonal antibody. (TA506052)

IHC Image

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-PIK3C2B mouse monoclonal antibody. (TA506052)

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OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Anti-PIK3C2B TrueMAB Antibody Clone 3B1

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

OriGene Data

Reference Data