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Home Antibody All anti-PICALM antibodies

Anti-PICALM Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306899
  • Rabbit Polyclonal PICALM Antibody
100ug 325 In Stock
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WB(1)
IF(1)
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Also for PICALM (NM_001008660)
cDNA Clone shRNA/siRNA Primer Pair Protein Request Antibody

OriGene Data

ImmunogenPICALM antibody was raised against a 15 amino acid peptide from near the amino terminus of human PICALM.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 1 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens phosphatidylinositol binding clathrin assembly protein (PICALM), transcript variant 2
Alternative NameCALM; CLTH; LAP
Database LinkNP_001008660
Entrez Gene 8301 Human
Entrez Gene 233489 Mouse
Entrez Gene 89816 Rat
FunctionPICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area, and is thought to be an important component of the coated pit internalization machinery. Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is also expressed in neurons and is present at the synapse where it facilitates the endocytosis of the synaptic vesicle protein VAMP2. Recent studies have identified variants of PICALM associated with Alzheimer's disease and have suggested this protein may play a role in the endocytosis and recycling of the amyloid protein precursor (APP).
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of PICALM in EL4 cell lysate with PICALM antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
IF Image
Immunofluorescence of PICALM in human brain tissue with PICALM antibody at 20 ug/mL.

 

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