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Home Antibody All anti-PIAS4 antibodies

Anti-PIAS4 Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319932
  • Rabbit Polyclonal PIAS4 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC414329) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for PIAS4 (NM_015897)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenPIAS4 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human PIAS4.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsELISA, WB: 1 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
BufferPIAS4 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification PIAS4 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens protein inhibitor of activated STAT, 4 (PIAS4)
Alternative NamePiasg; PIASY; ZMIZ6
Database LinkNP_056981
Entrez Gene 51588 Human
Entrez Gene 59004 Mouse
Entrez Gene 362827 Rat
FunctionPIAS4 Antibody: The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS4. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS4 interacts with p53 and blocks its ability to induce Bax and p21 transcription. PIAS4 is also important in the control of the ubiquitin-dependent proteasomal degradation of the Ets-1 transcription factor. PIAS4 has been implicated in the DNA-damage response pathway and is thought to work in combination with PIAS1 for the productive association of 53BP1, BRCA1 and RNF168.
Related PathwayTranscription Factors Ubiquitin mediated proteolysisJak-STAT signaling pathwayPathways in cancerSmall cell lung cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of PIAS4 in rat brain tissue lysate with PIAS4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
IHC Image
Immunohistochemistry of PIAS4 in rat brain tissue with PIAS4 antibody at 5 ug/mL.

 

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