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Anti-PIAS2 Antibody Polyclonal
Also for PIAS2 (NM_004671)
|PIAS2 antibody was raised against a 18 amino acid synthetic peptide near the amino terminus of human PIAS2.|
|Human, Mouse, Rat
|WB, IHC, IF
||WB: 1 - 2 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
|PIAS2 Antibody is supplied in PBS containing 0.02% sodium azide.|
|PIAS2 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens protein inhibitor of activated STAT, 2 (PIAS2), transcript variant beta|
|ARIP3; DIP; MIZ; MIZ1; PIASX; PIASX-ALPHA; PIASX-BETA; SIZ2; ZMIZ4|
|PIAS2 Antibody: The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS2. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS2 binds specifically to STAT4 following IL-12 stimulation and inhibits STAT4-mediated gene activation in human T cells. PIAS2 is a potent transcriptional activator of Bcl-2, but together with Bcl-6 can suppress the expression of Bcl-2.|
Jak-STAT signaling pathway
TGF Beta Signaling Pathway
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Western blot analysis of PIAS2 in rat brain tissue lysate with PIAS2 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of PIAS2 in rat brain tissue with PIAS2 antibody at 5 ug/mL.
Immunofluorescence of PIAS2 in rat brain tissue with PIAS2 antibody at 20 ?g/mL.