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Home Antibody All anti-PIAS2 antibodies

Anti-PIAS2 Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319767
  • Rabbit Polyclonal PIAS2 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401487) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)
IF(1)
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Also for PIAS2 (NM_004671)
cDNA Clone shRNA/siRNA Primer Pair Protein Antibody

OriGene Data

ImmunogenPIAS2 antibody was raised against a 18 amino acid synthetic peptide near the amino terminus of human PIAS2.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 - 2 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
BufferPIAS2 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification PIAS2 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens protein inhibitor of activated STAT, 2 (PIAS2), transcript variant beta
Alternative NameARIP3; DIP; MIZ; MIZ1; PIASX; PIASX-ALPHA; PIASX-BETA; SIZ2; ZMIZ4
Database LinkNP_004662
Entrez Gene 9063 Human
Entrez Gene 17344 Mouse
Entrez Gene 83422 Rat
FunctionPIAS2 Antibody: The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS2. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS2 binds specifically to STAT4 following IL-12 stimulation and inhibits STAT4-mediated gene activation in human T cells. PIAS2 is a potent transcriptional activator of Bcl-2, but together with Bcl-6 can suppress the expression of Bcl-2.
Related PathwayStem cell relevant signaling - JAK/STAT signaling pathwayStem cell - PluripotencyTranscription Factors Ubiquitin mediated proteolysisJak-STAT signaling pathwayPathways in cancerSmall cell lung cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of PIAS2 in rat brain tissue lysate with PIAS2 antibody at (A) 1 and (B) 2 ug/mL.
IHC Image
Immunohistochemistry of PIAS2 in rat brain tissue with PIAS2 antibody at 5 ug/mL.
IF Image
Immunofluorescence of PIAS2 in rat brain tissue with PIAS2 antibody at 20 ?g/mL.

 

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