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Home Antibody All anti-PDGFRB antibodies

Anti-PDGFRB PHOSPHO Antibody EP2137Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307429
  • Rabbit monoclonal antibody against PDGF Receptor beta Phospho (pY1009)(clone EP2137Y) (Phospho-Specific)
100ul 325 In Stock
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WB(1)

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding tyrosine 1009 of human PDGF receptor beta was used as an immunogen. This antibody detects PDGFR-beta phosphorylated on Tyrosine 1009. This antibody is predicted to work in human samples, based on sequence analysis only.
Clone NameEP2137Y IsotypeIgG1
Species ReactivityMouse (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameMus musculus platelet derived growth factor receptor, beta polypeptide (Pdgfrb), transcript variant 2
Alternative NameAI528809; CD140b; Pdgfr; PDGFR-1
Database LinkNP_032835
FunctionHuman platelet-derived growth factor (PDGF) receptor is a receptor tyrosine kinase whose activity induces various signalling cascades leading to cell growth and proliferation. Two major isoforms exist, PDGF receptor-a and PDGF receptor-beta. PDGF receptor-beta can only bind two specific PDGF isoforms, PDGF-beta and PDGF-delta (1,2). Upon ligand binding, the receptor undergoes autophosphorylation, allowing binding and activation of cytoplasmic SH2 domain-containing signal transduction molecules such as PI kinase, Grb2, and Src, among others (3). It has been shown that SHP-2 and PLC-gamma bind to PDGF receptor-beta that is phosphorylated at Tyrosine 1009 (4). Both Tyrosine 751 and 740 is required for PDGFR-beta mediated PI3 kinase activation. In particular, Tyrosine 751 is the docking site for P13 kinase (5).
Related Pathway

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WB Image
Western blot - Anti-PDGF Receptor beta (phospho Y1009) antibody [EP2137Y]; All lanes : Anti-PDGF Receptor beta (phospho Y1009) antibody [EP2137Y] at 1/10000 dilution.Lane 1 : NIH3T3 cell lysate, untreated.Lane 2 : NIH3T3 cell lysate, treated with PDGF.Predicted band size : 124 kDa.

 

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