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Anti-PDGFRB PHOSPHO Antibody EP2137Y
Also for PDGFRB (NM_008809)
|A phospho specific peptide corresponding to residues surrounding tyrosine 1009 of human PDGF receptor beta was used as an immunogen. This antibody detects PDGFR-beta phosphorylated on Tyrosine 1009. This antibody is predicted to work in human samples, based on sequence analysis only.|
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Mus musculus platelet derived growth factor receptor, beta polypeptide (Pdgfrb), transcript variant 2|
|AI528809; CD140b; Pdgfr; PDGFR-1|
|Human platelet-derived growth factor (PDGF) receptor is a receptor tyrosine kinase whose activity induces various signalling cascades leading to cell growth and proliferation. Two major isoforms exist, PDGF receptor-a and PDGF receptor-beta. PDGF receptor-beta can only bind two specific PDGF isoforms, PDGF-beta and PDGF-delta (1,2). Upon ligand binding, the receptor undergoes autophosphorylation, allowing binding and activation of cytoplasmic SH2 domain-containing signal transduction molecules such as PI kinase, Grb2, and Src, among others (3). It has been shown that SHP-2 and PLC-gamma bind to PDGF receptor-beta that is phosphorylated at Tyrosine 1009 (4). Both Tyrosine 751 and 740 is required for PDGFR-beta mediated PI3 kinase activation. In particular, Tyrosine 751 is the docking site for P13 kinase (5).|
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Western blot - Anti-PDGF Receptor beta (phospho Y1009) antibody [EP2137Y]; All lanes : Anti-PDGF Receptor beta (phospho Y1009) antibody [EP2137Y] at 1/10000 dilution.Lane 1 : NIH3T3 cell lysate, untreated.Lane 2 : NIH3T3 cell lysate, treated with PDGF.Predicted band size : 124 kDa.