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Anti-PDGFRB Phospho Antibody EP2136Y
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Also for PDGFRB (NM_001146268)
|A phospho specific peptide corresponding to residues surrounding Tyrosine 857 of human PDGF-Receptor ? was used as an immunogen. This antibody detects PDGF-Receptor ? phosphorylated at Tyrosine 857|
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Mus musculus platelet derived growth factor receptor, beta polypeptide (Pdgfrb), transcript variant 1|
|AI528809; CD140b; Pdgfr; PDGFR-1|
|Human platelet-derived growth factor (PDGF) receptor, is a receptor tyrosine kinase whose activity induces various signalling cascades leading to cell growth and proliferation. Phosphorylation of Tyrosine 857 (pY857) in the catalytic loop of the PDGF Receptor beta has been shown to increase kinase activity. Two major isoforms exist, PDGF receptor-? and PDGF receptor-?. PDGF receptor-? can only bind two specific PDGF isoforms, PDGF-? and PDGF-? (1,2). Upon ligand binding, the receptor undergoes autophosphorylation, allowing binding and activation of cytoplasmic SH2 domain-containing signal transduction molecules such as PI kinase (3), Grb2, and Src, among others. |
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Western blot analysis on NIH3T3 cell lysates using anti-Phospho-PDGF-Receptor β (pY857), 1:1000 dilution. Cells were either (A) untreated (B) treated with PDGF.