Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
Homo sapiens platelet-derived growth factor receptor, beta polypeptide (PDGFRB)
Synonyms:
CD140B; IBGC4; JTK12; PDGFR; PDGFR-1; PDGFR1
Immunogen
A synthetic peptide corresponding to residues in C-terminus of human PDGF receptor- ß was used as immunogen. The antibody does not cross-react with other CSF-1/PDGF receptor family members.
Buffer
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Human platelet-derived growth factor (PDGF) receptor, is a receptor tyrosine kinase whose activity induces various signalling cascades leading to cell growth and proliferation. Two major isoforms exist, PDGF receptor-a and PDGF receptor-ß. PDGF receptor-ß can only bind two specific PDGF isoforms, PDGF-ß and PDGF-? (1,2). Upon ligand binding, the receptor undergoes autophosphorylation, allowing binding and activation of cytoplasmic SH2 domain-containing signal transduction molecules such as PI kinase (3), Grb2, and Src, among others.
Related Pathway
Cytokine-cytokine receptor interaction
Focal Adhesion
MAPK signaling pathway
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