Human platelet-derived growth factor (PDGF) receptor, is a receptor tyrosine kinase whose activity induces various signalling cascades leading to cell growth and proliferation. Two major isoforms exist, PDGF receptor-a and PDGF receptor-ß. PDGF receptor-ß can only bind two specific PDGF isoforms, PDGF-ß and PDGF-? (1,2). Upon ligand binding, the receptor undergoes autophosphorylation, allowing binding and activation of cytoplasmic SH2 domain-containing signal transduction molecules such as PI kinase (3), Grb2, and Src, among others.
Cytokine-cytokine receptor interaction
MAPK signaling pathway
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