Anti-PDGFRA Antibody, EPR5480

Also for PDGFRA (NM_006206)

Gene Name	Homo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA)
Synonyms:	CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Immunogen	A synthetic peptide corresponding to residues at the C-terminus of human PDGF Receptor alpha was used as an immunogen.
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Clone Name	EPR5480	Isotype
Species Reactivity	Human, Mouse, Rat	Concentration
Purification	(Protein A or G Sepharose)
Guaranteed Application *	WB	Suggested Dilutions	WB: 1:10,000 - 50,000; IHC 1:250 - 500; ICC: 1:100 - 250; IP: 1:10 - 100;
Background	PDGF Receptor alpha is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes (1).
Related Pathway	Cytokine-cytokine receptor interaction Focal Adhesion MAPK signaling pathway

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WB Image

Western blot analysis on (A) SH-SY5Y and (B) C2C12 cell lysates using anti-PDGF Receptor alpha RabMAb.

WB Image

Western blot analysis on (A) human skeletal muscle, (B) human spleen, and (C) fetal brain lysates using anti-PDGF Receptor alpha RabMAb.

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Anti-PDGFRA Antibody EPR5480

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