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Anti-PDE4B TRUEMAB Antibody clone 3A10
TrueMAB Antibodies - Made against Authentic Protein Antigens
Also for PDE4B (NM_002600)
|Full length human recombinant protein of human PDE4B(NP_002591) produced in HEK293T cell.|
|WB, IHC, FC
||WB 1:500~2000, IHC 1:150, FLOW 1:100,
|PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography
|Homo sapiens phosphodiesterase 4B, cAMP-specific (PDE4B), transcript variant a|
|DPDE4; PDE4B5; PDEIVB|
|This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].|
Signaling by GPCR
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PDE4B (RC211956, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PDE4B.
Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-PDE4B monoclonal antibody.
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-PDE4B mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA503532)
Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-PDE4B mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA503532)
HEK293T cells transfected with either RC211956 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-PDE4B antibody(TA503532), and then analyzed by flow cytometry.