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Home Antibody All anti-PDE10A antibodies

Anti-PDE10A TRUEMAB Antibody clone 4A10

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA500888
  • PDE10A mouse monoclonal antibody, clone 4A10
  • FREE positive control: HEK293T cell transient overexpression lysate (LC416496) , 20ug
100ul $325 In Stock
CF500888
  • Carrier-free (BSA/glycerol-free) PDE10A mouse monoclonal antibody, clone 4A10
100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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WB(1)
FC(1)
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Also for PDE10A (NM_006661)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human PDE10A (NP_006652) produced in HEK293T cell.
Clone Nameclone 4A10 IsotypeIgG1
Species ReactivityHuman Concentration0.71 mg/ml
Guaranteed Application *WB, FC Suggested DilutionsWB:1:500; FC:1:50
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens phosphodiesterase 10A (PDE10A), transcript variant 2
Alternative NameFLJ11894; FLJ25677; HSPDE10A
Database LinkNP_006652
FunctionPhosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3'cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously,with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility,platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.
Related Pathway
Signaling by GPCR

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PDE10A (RC211181, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PDE10A.
FC Image
HEK293T cells transfected with either RC211181 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-PDE10A antibody(TA500888), and then analyzed by flow cytometry.

 

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