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Anti-PDE10A TRUEMAB Antibody clone 4A10
TrueMAB Antibodies - Made against Authentic Protein Antigens
Also for PDE10A (NM_006661)
|Full length human recombinant protein of human PDE10A (NP_006652) produced in HEK293T cell.|
|PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography (Protein A or G Sepharose)
|Homo sapiens phosphodiesterase 10A (PDE10A), transcript variant 2|
|FLJ11894; FLJ25677; HSPDE10A|
|Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3'cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously,with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility,platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.|
Signaling by GPCR
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PDE10A (RC211181, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PDE10A.
HEK293T cells transfected with either RC211181 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-PDE10A antibody(TA500888), and then analyzed by flow cytometry.