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Home Antibody All anti-PDE10A antibodies

Anti-PDE10A TRUEMAB Antibody clone 1B2

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA500635
  • anti-PDE10A mouse monoclonal antibody, clone 1B2
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC416496) , 20ug Explanation
100ul
30ul
379 In Stock
CF500635
  • Carrier-free (BSA/glycerol-free) PDE10A mouse monoclonal antibody, clone 1B2
100ug $450 3-4 Days
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WB(2)
IHC(1)
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Also for PDE10A (NM_006661)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull-length protein expressed in 293T cell transfected with human PDE10A expression vector
Clone Nameclone 1B2 IsotypeIgG1
Species ReactivityHuman Concentration0.6mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB 1:500, IHC 1:50,
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens phosphodiesterase 10A (PDE10A), transcript variant 2
Alternative NameFLJ11894; FLJ25677; HSPDE10A
Database LinkNP_006652
FunctionPhosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3'cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously,with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility,platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.
Related Pathway
Signaling by GPCR

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PDE10A (RC211181, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PDE10A .
WB Image
Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-PDE10A monoclonal antibody.
IHC Image
Immunohistochemical staining of paraffin-embedded endometrium tissue using anti-PDE10A mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA500635, Dilution 1:50)

 

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