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Anti-PC Antibody EPR7366


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal antibody against Pyruvate Carboxylase (PC)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400340) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Pyruvate Carboxylase was used as an immunogen.
Clone NameEPR7366 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY Suggested DilutionsWB: 1:1000 - 1:10000
Predicted MW Explanation 130 kDa
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens pyruvate carboxylase (PC), transcript variant 1
Alternative NamePCB
Database LinkNP_000911
Entrez Gene 5091 Human
Entrez Gene 18517 Mouse
Entrez Gene 25104 Rat
FunctionPyruvate carboxylase requires biotin and ATP to catalyze the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron, which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this protein have been associated with pyruvate carboxylase deficiency (1).
Related PathwayDruggable Genome Citrate cycle (TCA cycle)Pyruvate metabolismMetabolic pathways

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-PCB antibody [EPR7366]; All lanes : Anti-PCB antibody [EPR7366] at 1/1000 dilution.Lane 1 : Human fetal kidney lysate.Lane 2 : HepG2 lysate.Lane 3 : Human fetal liver lysate.Lane 4 : A549 lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 130 kDa.
WB Image
Western blot - Anti-PCB antibody [EPR7366]; All lanes : Anti-PCB antibody [EPR7366] at 1/1000 dilution.Lane 1 : Mouse brain lysate.Lane 2 : Rat brain lysate.Predicted band size : 130 kDa.
Assay Image
Other-Anti-PCB antibody [EPR7366](TA311022); Equilibrium disassociation constant (KD)..


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