Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
Homo sapiens PRKC, apoptosis, WT1, regulator (PAWR)
Synonyms:
Par-4; PAR4
Immunogen
A synthetic peptide corresponding to residues in human PAR4 was used as an immunogen.
Buffer
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Prostate apoptosis response protein (PAR4) is a proapoptotic protein with intracellular functions in the cytoplasm and nucleus, capable of suppressing tumors (1). Extracellular PAR4 induces apoptosis by binding to the stress response protein, glucose-regulated protein-78 (GRP78), via an extrinsic pathway (1). PAR4 contains leucine zipper and death domains that are upregulated in prostate cancer cells and hippocampal neurons induced to undergo apoptosis (2). Alzheimer's and Parkinson's diseases are both targets for PAR-4 in treatments that block its expression, preventing neuronal cell death (3). In Parkinson's disease, the death of dopaminergic neurons follows a degenerative pathway that circumvents the apoptotic induction of PAR-4 (4). An isoform of PAR-4, PAR-4/p33, prevents apoptosis in neural stem cells and does not activate caspase 3 (5).
Related Pathway
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