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Home Antibody All anti-Parva antibodies

Anti-Parva PHOSPHO Antibody EPR2174

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307078
  • Rabbit monoclonal antibody against Actopaxin/Parvin Phospho (pS8) (clone EPR2174 ) (Phospho-Specific)
100ul 325 3-7 Days
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WB(1)
IF(1)
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Also for Parva (NM_018222)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding serine 8 of human Parvin was used as an immunogen. This antibody detects Actopaxin phosphorlyated on serine 8.
Clone NameEPR2174 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsICC/IF: 1:100 - 1:250; WB: 1:2500 - 1:5000
Predicted MW Explanation 42 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens parvin, alpha (PARVA)
Alternative NameCH-ILKBP; MXRA2
Database LinkNP_060692
Entrez Gene 55742 Human
Entrez Gene 57342 Mouse
Entrez Gene 57341 Rat
FunctionActopaxin (also named Parvin, Parva) is a member of the alpha actinin superfamily containing a single alpha-actinin-like actin-binding domain. The Parvin family plays a role in cell adhesion and cytoskeleton organization. Analysis of Actopaxin and its para- and orthologues suggest, that the parvins represent a new family of alpha-actinin-related proteins that mediate cell-matrix adhesion (1). Actopaxin as a widely expressed protein that binds directly to both F-actin and paxillin LD1 and LD4 motifs. It exhibits robust focal adhesion localization in several cultured cell types but is not found along the length of the associated actin-rich stress fibers. Actopaxin colocalizes with paxillin to rudimentary focal complexes at the leading edge of migrating cells. Results suggest an important role for actopaxin in integrin-dependent remodeling of the actin cytoskeleton during cell motility and cell adhesion (2).
Related Pathway Focal adhesion

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Parvin alpha (phospho S8) antibody [EPR2174]; All lanes : Anti-Parvin alpha (phospho S8) antibody [EPR2174] at 1/5000 dilution.Lane 1 : A549 cell lysate.Lane 2 : A549 cell lysate treated with LP.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 42 kDa.Observed band size : 42 kDa.
IF Image
Immunocytochemistry/ Immunofluorescence - Parvin alpha (phospho S8) antibody [EPR2174]; Immunofluorescent staining of HeLa cells using TA307078 at 1/100 dilution.

 

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