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Anti-PARN TRUEMAB Antibody Clone OTI4E12

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA802650 PARN mouse monoclonal antibody,clone OTI4E12 100ul $325 In Stock
LC419233 PARN HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF802650 Carrier-free (BSA/glycerol-free) PARN mouse monoclonal antibody, clone OTIE12 (formerly E12) 100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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WB(2)
IHC(6)

OriGene Data

ImmunogenHuman recombinant protein fragment corresponding to amino acids 1-266 of human PARN (NP_002573) produced in E.coli.
Clone NameClone OTI4E12 IsotypeIgG2a
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB, IHC Suggested Dilutions WB 1:2000,
Predicted MW Explanation 73.3 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens poly(A)-specific ribonuclease (PARN), transcript variant 1
Alternative NameDAN
Database LinkNP_002573
Entrez Gene 5073 Human
FunctionThe protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
Related PathwayTranscription Factors RNA degradation

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PARN (RC207220, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PARN.
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Western blot analysis of  HT29 cell lysate (35ug) by using anti-PARN monoclonal antibody. Dilution: 1:500
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-PARN mouse monoclonal antibody. (TA802650) Dilution: 1:150
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-PARN mouse monoclonal antibody. (TA802650) Dilution: 1:150
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-PARN mouse monoclonal antibody. (TA802650) Dilution: 1:150
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Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-PARN mouse monoclonal antibody. (TA802650) Dilution: 1:150
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Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-PARN mouse monoclonal antibody. (TA802650) Dilution: 1:150
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Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-PARN mouse monoclonal antibody. (TA802650) Dilution: 1:150
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