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Home Antibody All anti-PARL antibodies

Anti-PARL Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306629
  • Rabbit Polyclonal PARL Antibody
100ug 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenPARL antibody was raised against a 15 amino acid peptide from near the amino terminus of human PARL.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 1 - 2 ug/ml, ICC: 2.5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens presenilin associated, rhomboid-like (PARL), transcript variant 2
Alternative NamePRO2207; PSARL; PSARL1; PSENIP2; RHBDS1
Database LinkNP_001032728
FunctionPARL is a mitochondrial integral membrane protein and a member of the highly conserved rhomboid superfamily of membrane proteins. PARL is required for the control of apoptosis during postnatal growth and is required for the processing of OPA1, a protein that prevents the release of cytochrome C from the mitochondria in response to apoptotic signals. In lymphocytes and neurons, PARL’s association with other proteins, such as the Bcl-2 family-related protein Hax1 and Omi can lead to the proteolytic processing of Omi by PARL, preventing the accumulation of Bax, thereby suppressing apoptosis. Variations in this gene have been associated with increased risk for type 2 diabetes. PARL may also play a role in the progression of Alzheimer’s disease through its associations with presenilin-1 and -2. Despite its predicted molecular weight of ~42kDa, PARL is observed at a higher molecular weight in SDS-PAGE. Multiple isoforms of PARL are known to exist.
Related Pathway

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WB Image
Western blot analysis of PARL in 3T3 cell lysate with PARL antibody at (A) 1 and (B) 2 ug/mL.
IF Image
Immunocytochemistry of PARL in 3T3 cells with PARL antibody at 2.5 ug/mL.

 

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