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Home Antibody All anti-PAPPA2 antibodies

Anti-PAPPA2 Antibody Polyclonal

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SKU Description Amount Price Availability*  
TA319996 Rabbit Polyclonal PLAC3 Antibody 100ug $325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenPLAC3 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human PLAC3.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 1 ug/ml, ICC: 10 ug/ml, IF: 20 ug/ml
BufferPLAC3 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification PLAC3 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens pappalysin 2 (PAPPA2), transcript variant 1
Alternative NamePAPP-A2; PAPP-E; PAPPE; PLAC3
Database LinkNP_064714
Entrez Gene 60676 Human
Entrez Gene 23850 Mouse
Entrez Gene 364027 Rat
FunctionPLAC3 Antibody: PLAC3 (placenta-specific protein 3), also known as PAPP-A2, is a metalloproteinase that cleaves the insulin-like growth factor-binding protein (IGFBP)-5 in a IGF-independent fashion. It has been suggested that the cleavage of IGFBP-5 and to a lesser extent IGFBP-3 produced in the maternal decidua promotes feto-placental growth. Recent studies have shown elevated levels of PLAC3 in hypertensive disorders of pregnancy including preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome.
Related PathwaySecreted ProteinProtease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of PLAC3 in HeLa cell lysate with PLAC3 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunofluorescence of PLAC3 in HeLa cells with PLAC3 antibody at 20 ug/mL.
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