Home Antibody All anti-PALB2 antibodies
Anti-PALB2 GAT Antibody Polyclonal
Generated by Genomic Immunization
Also for PALB2 (NM_024675)
|DNA immunization. This antibody is specific for the N Terminus Region of the target protein (NM_024675).|
|WB, ELISA, IHC
||WB: 1:5000-1:20000; ELISA: 1:100-1:2000
|20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
|This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
|Homo sapiens partner and localizer of BRCA2 (PALB2)|
Entrez Gene 79728 Human
|PALB2 (partner and localizer of BRCA2) interacts with BRCA2 and promotes BRCA2 localization and stability. PALB2 is also known as FANCN. Bi-allelic mutations in PALB2 result in Fanconi anemia disorder and breast cancer susceptibility. At the cellular level, PALB2 is important to the DNA damage response and chromosome stability and is essential to BRCA2 function.|
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Western Blot: PALB2 Antibody - Western Blot was performed using affinity purified SEQer PALB2 antibody, aa(99-198) antibody. The lanes contain 5-30ug of a whole cell extract. Final concentration of antibodies = 0.1ug/ml (1:10,000 dilution). The blot was probed overnight with the SEQer PALB2 antibody, aa(99-198) antibody. Blot was then washed according to protocol and probed with goat-anti-Rabbit-HRP conjugate at 1:5000 dilution, washed and developed using chemiluminescence (film exposure 5-30sec). The protein was detected as represented by the band shown.
Immunohistochemistry: PALB2 Antibody - Normal and malignant tissues exhibited strong nuclear membrane and additional cytoplasmic staining. Testicular tumors and prostate cancers showed in most cases moderate cytoplasmic positivity. Image and statement courtesy of the Human Protein Atlas (HPA).