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Home Antibody All anti-PALB2 antibodies

Anti-PALB2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306814
  • Rabbit Polyclonal PALB2 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC411136) , 20ug
100ug 325 In Stock
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WB(1)

OriGene Data

ImmunogenPALB2 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human PALB2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens partner and localizer of BRCA2 (PALB2)
Alternative NameFANCN; PNCA3
Database LinkNP_078951
FunctionThe breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments. At least four isoforms of PALB2 are known to exist.
Related Pathway

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WB Image
Western blot analysis of PALB2 in SK-N-SH cell lysate with PALB2 antibody at (A) 1 and (B) 2 µg/ml.

 

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