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Home Antibody All anti-PAK7 antibodies

Anti-PAK7 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306115
  • Rabbit Polyclonal PAK5 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC412537) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenPAK5 antibody was raised against a 13 amino acid peptide from near the center of human PAK5.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 2 - 4 ug/ml, ICC: 2 ug/ml, IF: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens p21 protein (Cdc42/Rac)-activated kinase 7 (PAK7), transcript variant 1
Alternative NamePAK5
Database LinkNP_065074
Entrez Gene 57144 Human
FunctionThe p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK5 was initially identified as a kinase expressed primarily in brain that while possessing a kinase domain and GTPase binding domain similar to PAK4 and PAK6, is completely different from both. Expression of PAK5 in neural based cell lines resulted in neurite outgrowth suggesting that PAK5 may be involved in regulating the cytoskeletal changes necessary for promoting neurite outgrowth. Other experiments suggest that unlike the other PAKs, PAK5 may inhibit apoptosis by phosphorylating the Bcl-2 family member Bad.
Related PathwayProtein KinaseDruggable Genome ErbB signaling pathwayAxon guidanceFocal adhesionT cell receptor signaling pathwayRegulation of actin cytoskeletonRenal cell carcinomaMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of PAK5 in T24 lysate with PAK5 antibody at (A) 2 and (B) 4 ug/mL.
IF Image
Immunocytochemistry of PAK5 in K562 cells with PAK5 antibody at 2 ug/mL.

 

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