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Anti-PAK3 Antibody EP797Y
Also for PAK3 (NM_002578)
|A synthetic peptide corresponding to residues in the N-terminus of human PAK3 was used as immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:10,000-50,000; IHC: 1:100-250; ICC: 1: 100-250; IP: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 3 (PAK3), transcript variant 2|
|bPAK; CDKN1A; hPAK3; MRX30; MRX47; OPHN3; PAK3beta|
|PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]. |
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Western blot - PAK3 antibody [EP797Y]; Anti-PAK3 antibody [EP797Y] at 1/50000 dilution + fetal brain lysate at 10 µg.Predicted band size : 62 kDa.Observed band size : 65 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PAK3 antibody [EP797Y]; ab40808 at a 1:100 dilution staining PAK3 in human brain glioma.