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Home Antibody All anti-PAK2 antibodies

Anti-PAK2 Antibody


Specifications Citations (1) Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306346 Rabbit Polyclonal PAK2 Antibody 100ug $325 In Stock
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OriGene Data

ImmunogenPAK2 antibody was raised against a 14 amino acid peptide from near the amino terminus of human PAK2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 0.5 - 2 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens p21 protein (Cdc42/Rac)-activated kinase 2 (PAK2)
Alternative NamePAK65; PAKgamma
Database LinkNP_002568
Entrez Gene 5062 Human
Entrez Gene 224105 Mouse
Entrez Gene 29432 Rat
FunctionThe p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6, and are not activated by Cdc42/Rac binding. Of the six PAK proteins, only PAK2 is ubiquitously expressed and cleaved by caspase-3. This cleavage removes the amino-terminal regulatory domain and generates a constitutively active kinase fragment. Recent experiments have shown that following cleavage, the active fragment is myristoylated and directed to the plasma membrane and membrane ruffles where it promotes cell death via increased signaling through the c-Jun N-terminal kinase pathway, but without compromising mitochondrial integrity.
Related PathwayProtein KinaseDruggable Genome MAPK signaling pathwayErbB signaling pathwayAxon guidanceFocal adhesionT cell receptor signaling pathwayRegulation of actin cytoskeletonMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of PAK2 in Jurkat lysate with PAK2 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.

WB Image
Figure from citation: Western Blot of PAK2 protein level by using anti-PAK2 antibody in cell lysates from the thymi of Pak2F/F (WT), Pak2F/+; Lck-Cre (HET) and Pak2F/F; Lck-Cre (KO) mice. View Citation

IHC Image
Immunohistochemistry of PAK2 in mouse spleen tissue with PAK2 antibody at 10 ug/ml.

IF Image
Immunofluorescence of PAK2 in mouse spleen tissue with PAK2 antibody at 20 ug/mL.


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