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Home Antibody All anti-P4HB antibodies

Anti-P4HB Antibody

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SKU Description Amount Price Availability*  
TA308403
  • Rabbit Polyclonal antibody to PDI (prolyl 4-hydroxylase, beta polypeptide)
100ul $325 In Stock

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WB(2)
IHC(2)
IF(1)

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 23 and 227 of PDI (Uniprot ID#P07237)
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse (Predicted: Chimpanzee) Concentration1mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:10000
Predicted MW Explanation 57kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Chimpanzee (100%)

Reference Data

Target NameHomo sapiens prolyl 4-hydroxylase, beta polypeptide (P4HB)
Alternative NameDSI; ERBA2L; GIT; P4Hbeta; PDI; PDIA1; PHDB; PO4DB; PO4HB; PROHB
Database LinkNP_000909
Entrez Gene 5034 Human
Entrez Gene 18453 Mouse
FunctionThis gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq]
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Sample (20 ug of whole cell lysate). A: mouse liver. 7.5% SDS PAGE. TA308403 diluted at 1:10000.
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Sample(30 ug of whole cell lysate). A:293T. B:A431. C:H1299. 7.5% SDS PAGE. TA308403 diluted at 1:500
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Immunohistochemical analysis of paraffin-embedded H520 xenograft, using PDI(TA308403) antibody at 1:100 dilution.
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PDI antibody [N1N3] detects PDI protein at cytosol and membrane on mouse colon by immunohistochemical analysis. Sample: Paraffin-embedded mouse colon. PDI antibody [N1N3] (TA308403) dilution: 1:500.
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Immunofluorescence analysis of methanol-fixed A431, using PDI(TA308403) antibody at 1:200 dilution.
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