Home Antibody All anti-P4HB antibodies
Also for P4HB (NM_000918)
|Recombinant fragment corresponding to a region within amino acids 23 and 227 of PDI (Uniprot ID#P07237)|
|Human, Mouse (Predicted: Chimpanzee)
|WB, IHC, IF
||ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:10000
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Chimpanzee (100%)
|Homo sapiens prolyl 4-hydroxylase, beta polypeptide (P4HB)|
|DSI; ERBA2L; GIT; P4Hbeta; PDI; PDIA1; PHDB; PO4DB; PO4HB; PROHB|
Entrez Gene 5034 Human
Entrez Gene 18453 Mouse
|This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq]|
|Druggable Genome |
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Sample (20 ug of whole cell lysate). A: mouse liver. 7.5% SDS PAGE. TA308403 diluted at 1:10000.
Sample(30 ug of whole cell lysate). A:293T. B:A431. C:H1299. 7.5% SDS PAGE. TA308403 diluted at 1:500
Immunohistochemical analysis of paraffin-embedded H520 xenograft, using PDI(TA308403) antibody at 1:100 dilution.
PDI antibody [N1N3] detects PDI protein at cytosol and membrane on mouse colon by immunohistochemical analysis. Sample: Paraffin-embedded mouse colon. PDI antibody [N1N3] (TA308403) dilution: 1:500.
Immunofluorescence analysis of methanol-fixed A431, using PDI(TA308403) antibody at 1:200 dilution.