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Home Antibody All anti-OTX2 antibodies

Anti-OTX2 Antibody EPR3347

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307062
  • Rabbit monoclonal antibody against OTX2(clone EPR3347)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC411946) , 20ug
100ul 325 3-7 Days
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WB(2)
IHC(1)
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Also for OTX2 (NM_021728)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human OTX2 was used as an immunogen. This antibody is predicted to cross-react with OTX1 based on sequence analysis.
Clone NameEPR3347 IsotypeIgG
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsIHC: 1:100 - 250, WB: 1:1,000 - 10,000,
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 1
Alternative NameCPHD6; MCOPS5
Database LinkNP_068374
FunctionHomeobox protein OTX2 is a member of the bicoid sub-family of homeodomain-containing transcription factors. It acts as a transcription factor and is reported to play a role in brain and sensory organ development (1); more specifically, forebrain and eye development (2). The OTX2 is required to determine mesencephalic versus metencephalic (cerebellum/pons) territory during embryogenesis. This function of OTX2 primarily involves positioning and maintaining the mid-hindbrain organizer at the border between midbrain and anterior hindbrain (3). OTX2 is expressed during development in the neuroepithelium of most of the forebrain and midbrain, including the eye domain. In mice, complete elimination of the OTX2 function results in the absence of the forebrain and embryonic lethality (4). Defects in OTX2 are the caused of microphthalmia syndromic type 5, a clinically heterogeneous disorder of the eye formation (5).
Related Pathway

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WB Image
Western blot - Anti-Otx1 + Otx2 antibody [EPR3347]; Anti-Otx1 + Otx2 antibody [EPR3347] at 1/1000 dilution + Y79 cell lysate at 10 µg.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 32 kDa.
WB Image
Western blot - Anti-Otx1 + Otx2 antibody [EPR3347]; Anti-Otx1 + Otx2 antibody [EPR3347] at 1 µg/ml + OTX1 Recombinant Protein at 0.1 µg.Secondary.Goat polyclonal Secondary Antibody to Rabbit IgG - H&L (HRP), pre-adsorbed at 1/5000 dilution.developed using the ECL technique.Performed under reducing conditions.Predicted band size : 32 kDa.Observed band size : 75 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Otx1 + Otx2 antibody [EPR3347]; Paraffin embedded Human brain tissue labelled with TA307062 at 1/100 dilution.

 

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