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Anti-OTX2 Antibody EPR3348

* Buy one primary antibody, get 50% off a GAPDH loading control antibody.

WB(1)

OriGene Data

Immunogen	A synthetic peptide corresponding to residues in human OTX2 was used as an immunogen.
Clone Name	EPR3348	Isotype	Rabbit IgG
Species Reactivity	Human	Concentration
Guaranteed Application *	WB	Suggested Dilutions	WB: 1:1,000 - 10,000,
Buffer	Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Purification	(Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 1
Alternative Name	CPHD6; MCOPS5
Database Link	NP_068374
Function	Homeobox protein OTX2 is a member of the bicoid sub-family of homeodomain-containing transcription factors. It acts as a transcription factor and is reported to play a role in brain and sensory organ development (1); more specifically, forebrain and eye development (2). The OTX2 is required to determine mesencephalic versus metencephalic (cerebellum/pons) territory during embryogenesis. This function of OTX2 primarily involves positioning and maintaining the mid-hindbrain organizer at the border between midbrain and anterior hindbrain (3). OTX2 is expressed during development in the neuroepithelium of most of the forebrain and midbrain, including the eye domain. In mice, complete elimination of the OTX2 function results in the absence of the forebrain and embryonic lethality (4). Defects in OTX2 are the caused of microphthalmia syndromic type 5, a clinically heterogeneous disorder of the eye formation (5).
Related Pathway

Related Lysate from OriGene • Transient overexpression lysate of orthodenticle homeobox 2 (OTX2), transcript variant 1 Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • OTX2 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • OTX2 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Otx2 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • OTX2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Otx2 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 1 as transfection-ready DNA • Lenti ORF clone of Human orthodenticle homeobox 2 (OTX2), transcript variant 1 , Myc-DDK-tagged • Lenti ORF clone of Human orthodenticle homeobox 2 (OTX2), transcript variant 1, mGFP tagged • GFP-tagged ORF clone of Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 1 as transfection-ready DNA Related cDNA Clones • Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 1 as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)