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Anti-OTUD5 Antibody


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SKU Description Amount Price Availability*  
  • Rabbit Polyclonal OTUD5 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC427830) , 20ug Explanation
100ug $325 3-7 Days

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart


OriGene Data

ImmunogenOTUD5 antibody was raised against a 13 amino acid peptide near the carboxy terminus of the human OTUD5.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens OTU deubiquitinase 5 (OTUD5), transcript variant 2
Alternative NameDUBA
Database LinkNP_001129629
Entrez Gene 55593 Human
Entrez Gene 54644 Mouse
Entrez Gene 363452 Rat
FunctionOTUD5 is a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and OTUD5 has been shown to suppress the type I interferon (IFN-I)-dependent innate immune response by cleaving the polyubiquitin chain from TRAF3, an essential type I interferon adaptor protein. Cleavage results in disassociation of TRAF3 from a downstream signaling complex containing TBK1 and the disruption of the IFN-I signaling cascade, indicating that OTUD5 acts as a negative regulator of innate immune responses. It has been suggested that by suppressing IFN-I production, OTUD5 may function to inhibit the emergence of certain autoimmune disorders such as systemic lupus erythematosus. Multiple isoforms of OTUD5 are known to exist.
Related PathwayProtease RIG-I-like receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of OTUD5 in human kidney lysate with OTUD5 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry of OTUD5 in mouse kidney tissue with OTUD5 antibody at 2.5 ug/ml.


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