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Home Antibody All anti-ORAI3 antibodies

Anti-ORAI3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306420
  • Rabbit Polyclonal ORAI3 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC403460) , 20ug
100ug 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenORAI3 antibody was raised against a 15 amino acid peptide from near the amino terminus of human ORAI3.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 - 4 ug/ml, ICC: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens ORAI calcium release-activated calcium modulator 3 (ORAI3)
Alternative NameTMEM142C
Database LinkNP_689501
FunctionAntigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2.
Related Pathway

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WB Image
Western blot analysis of ORAI3 in A20 cell lysate with ORAI3 antibody at (A) 1, (B) 2 and (C) 4 ug/mL.
IF Image
Immunocytochemistry of ORAI3 in A20 cells with ORAI3 antibody at 10 ug/mL.

 

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