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Home Antibody All anti-OPTN antibodies
UltraMAB

Anti-OPTN GAT Antibody Polyclonal

Generated by Genomic Immunization

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA590464
  • Rabbit Polyclonal Optineurin Antibody
100ug 325 In Stock
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WB(3)
IHC(6)
IF(1)
ELISA(1)

OriGene Data

ImmunogenDNA immunization. This antibody is specific for the Middle Region of the target protein.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman , Dog , Rat , Monkey , Mouse Concentration0.67445
Guaranteed Application *WB, ELISA, IHC, IF Suggested Dilutions WB 1:5000~20000, IHC 1:150,ELISA 1:100-1:2000
Buffer20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
Purification The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
Note This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT

Reference Data

Target NameHomo sapiens optineurin (OPTN), transcript variant 2
Alternative NameALS12; FIP2; GLC1E; HIP7; HYPL; NRP; TFIIIA-INTP
Database LinkNP_068815
FunctionThis gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq]
Related Pathway

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WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY OPTN (RC221792, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-OPTN.
WB Image
Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-OPTN polyclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
WB Image
Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 11; Lane 2: RT-4; Lane 3: U-251 MG; Lane 4: Human Plasma; Lane 5: Liver; Lane 6: TonsilThis validation was performed by Protein Atlas and the presentation of data is for informational purposes only.
ELISA Image
ELISA: Optineurin Antibody
IHC Image
Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-OPTN rabbit polyclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA590464)
IHC Image
Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-OPTN rabbit polyclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA590464)
IHC Image
Immunohistochemical staining of paraffin-embedded Human liver tissue using anti-OPTN rabbit polyclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA590464)
IHC Image
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-OPTN rabbit polyclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA590464)
IHC Image
Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-OPTN rabbit polyclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA590464)
IHC Image
Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in glandular cells.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.
IF Image
Immunofluorescent staining of human cell line A-431 shows positivity in cytoplasm.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.

 

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