Home All anti-OGG1 antibodies
Anti-OGG1 Antibody EPR4664(2)
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Also for OGG1 (NM_002542)
|A synthetic peptide corresponding to residues at the C-terminus of human OGG1 was used as an immunogen.|
||WB: 1:1,000 - 10,000; IHC 1:100 - 250; IP: 1:10 - 100; FC: 1:10 - 100;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens 8-oxoguanine DNA glycosylase (OGG1), nuclear gene encoding mitochondrial protein, transcript variant 1a|
|HMMH; HOGG1; MUTM; OGH1|
|OGG1 is the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of OGG1 classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization (1). |
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Western blot analysis on (A) human cerebellum, (B) HeLa, (C) JAR, and (D) HepG2 cell lysates using anti-OGG1 RabMAb.