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Home Antibody All anti-Nog antibodies

Anti-Nog TRUEMAB Antibody clone 1H8

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA500029
  • Noggin (Noggin) mouse monoclonal antibody, clone 1H8
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401672) , 20ug Explanation
100ul 379 In Stock
CF500029
  • Carrier-free (BSA/glycerol-free) Noggin mouse monoclonal antibody, clone 1H8
100ug $450 3-4 weeks
This antibody qualifies for Season of Giving promotion: Earn $50 Amazon gift card (use promo code SPQ12081) or donation to Cancer.org (promo code SPQ12082) with $600 purchase of UltraMAB or TrueMAB. Click for details
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WB(3)
IHC(2)
IF(1)
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Also for Nog (NM_005450)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenHuman recombinant protein fragment corresponding to amino acids 28-232 of human noggin (NP_005441) produced in E.coli.
Clone Nameclone 1H8 IsotypeIgG2b
Species ReactivityHuman Concentration0.26 mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB 1:20000~40000, IHC 1:50, IF 1:100,
Predicted MW Explanation 23.7 kDa
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens noggin (NOG)
Alternative NameSYM1; SYNS1
Database LinkNP_005441
Entrez Gene 9241 Human
FunctionNoggin is a secreted polypeptide which binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, it may have a principal role in creating morphogenic gradients. Noggin appears to have pleiotropic effect, both early in development as well as in later stages. The results of the mouse knockout of the ortholog suggest that noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse.
Related PathwaySecreted ProteinDruggable Genome TGF-beta signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY Nog (RC205020, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-Nog.
WB Image
Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-Nog monoclonal antibody.
WB Image
Noggin antibody (1H8) at 1:40000 + Recombinant human Noggin (Cat# RC205020)
IHC Image
Immunohistochemical staining of paraffin-embedded Human lung tissue using anti-Nog mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500029)
IHC Image
Immunohistochemical staining of paraffin-embedded Human Ovary tissue using anti-Nog mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500029)
IF Image
Anti-Nog mouse monoclonal antibody (TA500029) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY Nog(RC205020).

 

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