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Home Antibody All anti-NXF1 antibodies

Anti-NXF1 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA308021 Rabbit Polyclonal antibody to TAP (nuclear RNA export factor 1) 100ul $325 3-7 Days
LC425934 NXF1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(2)
IF(1)

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 449 and 619 of TAP (Uniprot ID#Q9UBU9)
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse (Predicted: Pig, Rat, Bovine) Concentration6.24mg/ml
Guaranteed Application *WB, IF Suggested DilutionsICC/IF:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 70kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Affinity purified by Protein A.
Note Seq homology of immunogen across species: Pig (96%), Rat (97%), Bovine (97%)

Reference Data

Target NameHomo sapiens nuclear RNA export factor 1 (NXF1), transcript variant 2
Alternative NameMEX67; TAP
Database LinkNP_001074960
Entrez Gene 10482 Human
Entrez Gene 53319 Mouse
Entrez Gene 59087 Rat
FunctionThis gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Sample (50 ug of whole cell lysate). A: Mouse brain. 7.5% SDS PAGE. TA308021 diluted at 1:1000.
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Sample (30 ug of whole cell lysate). A: A431 . 7.5% SDS PAGE. TA308021 diluted at 1:1000.
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Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using TAP(TA308021) antibody at 1:200 dilution.
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