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Anti-NUMB Antibody Polyclonal
Also for NUMB (NM_001005743)
|NUMB antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human NUMB.|
|Human, Mouse, Rat
||ELISA, WB: 0.25 - 0.5 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
|NUMB Antibody is supplied in PBS containing 0.02% sodium azide.|
|NUMB Antibody is affinity chromatography purified via peptide column. (Protein A or G Sepharose)
|Homo sapiens numb homolog (Drosophila) (NUMB), transcript variant 1|
|C14orf41; c14_5527; S171|
|NUMB Antibody: NUMB, the mammalian homolog to the Drosophila asymmetric cell fate determinant NUMB, is thought to share several features molecular mechanisms in mammalian cells, generating asymmetric cell divisions during neurogenesis in vertebrate development as well as in hematopoietic stem cells. NUMB has been shown to inhibit Notch signaling, and is itself regulated by ubiquitinylation by MDM2. NUMB has also been shown to help activate the tumor suppressor p53, suggesting that loss of NUMB in cancerous cells would not only activate the potential oncogene Notch, but diminish the tumor suppressing effect of p53.|
Delta-Notch Signaling Pathway
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Western blot analysis of NUMB in mouse lung tissue lysate with NUMB antibody at (A) 0.25 and (B) 0.5 ug/mL.
Immunohistochemistry of NUMB in human lung tissue with NUMB antibody at 5 ug/mL.