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Home Antibody All anti-NUMB antibodies

Anti-NUMB Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319756
  • Rabbit Polyclonal NUMB Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC423643) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
IF(1)
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Also for NUMB (NM_001005743)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenNUMB antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human NUMB.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 0.25 - 0.5 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
BufferNUMB Antibody is supplied in PBS containing 0.02% sodium azide.
Purification NUMB Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens numb homolog (Drosophila) (NUMB), transcript variant 1
Alternative NameC14orf41; c14_5527; S171
Database LinkNP_001005743
FunctionNUMB Antibody: NUMB, the mammalian homolog to the Drosophila asymmetric cell fate determinant NUMB, is thought to share several features molecular mechanisms in mammalian cells, generating asymmetric cell divisions during neurogenesis in vertebrate development as well as in hematopoietic stem cells. NUMB has been shown to inhibit Notch signaling, and is itself regulated by ubiquitinylation by MDM2. NUMB has also been shown to help activate the tumor suppressor p53, suggesting that loss of NUMB in cancerous cells would not only activate the potential oncogene Notch, but diminish the tumor suppressing effect of p53.
Related Pathway
Delta-Notch Signaling Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of NUMB in mouse lung tissue lysate with NUMB antibody at (A) 0.25 and (B) 0.5 ug/mL.
IHC Image
Immunohistochemistry of NUMB in human lung tissue with NUMB antibody at 5 ug/mL.
IF Image
Immunofluorescence of NUMB in human lung tissue with NUMB antibody at 20 ug/mL.

 

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