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Home All anti-NTRK2 antibodies
Anti-NTRK2 Phospho Antibody EP1298Y
TrueMAB™ Antibodies - Made against Authentic Protein Antigens
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for NTRK2 (NM_001007097)
OriGene Data
| A phospho specific peptide corresponding to residues surrounding Tyrosine 817 of human TrkB was used as an immunogen. This antibody detects TrkB phosphorylated at Y817. |
| EP1298Y |
IgG |
| Human, Rat |
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| WB |
WB: 1:5000 10,000; ICC: 1:50; IP: 1:40 |
| 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
| (Protein A or G Sepharose) |
Reference Data
| Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b |
| GP145-TrkB; trk-B; TRKB |
| NP_001007098 |
| There is increasing evidence that neutrophins and their receptors play an important role in regulating development of both the central and the peripheral nervous systems (1). The binding of neurotrophin ligands to their respective Trk cellular receptors initiates intracellular signals essential for the growth and survival of neurons. The site of neurotrophin binding has been located to the fifth extracellular domain of the Trk receptor, with this region regulating both the affinity and specificity of Trk receptor:neurotrophin interaction (2). The TrkB receptor tyrosine kinase and its ligand, BDNF, have an essential role in certain forms of synaptic plasticity. Results provide evidence that TrkB mediates hippocampal plasticity via recruitment of PLCgamma, and by subsequent phosphorylation of CaMKIV (3). Also, TrkB has been found to be essential to the development of GABAergic neurons and regulates synapse formation in addition to its role in the development of axon terminals (4). |
MAPK signaling pathway |
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* OriGene provides validated application data and protocol, with money back guarantee.
WB Image
Western blot analysis on rat brain lysates using anti-Phospho-TrkB (pY817), 1:10,000 dilution. Lysates were either (A) untreated or (B) treated with AP.
Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:
- HRP
- Biotin
- PE
- FITC
- DyLight® 488
- DyLight® 550
- DyLight® 594
- DyLight® 633
* DyLight is a trademark of Thermo-Fisher Scientific
Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.
Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)
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