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Anti-NTRK2 Phospho Antibody EP1298Y
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Also for NTRK2 (NM_001007097)
|A phospho specific peptide corresponding to residues surrounding Tyrosine 817 of human TrkB was used as an immunogen. This antibody detects TrkB phosphorylated at Y817.|
||WB: 1:5000 10,000; ICC: 1:50; IP: 1:40
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b|
|GP145-TrkB; trk-B; TRKB|
|There is increasing evidence that neutrophins and their receptors play an important role in regulating development of both the central and the peripheral nervous systems (1). The binding of neurotrophin ligands to their respective Trk cellular receptors initiates intracellular signals essential for the growth and survival of neurons. The site of neurotrophin binding has been located to the fifth extracellular domain of the Trk receptor, with this region regulating both the affinity and specificity of Trk receptor:neurotrophin interaction (2). The TrkB receptor tyrosine kinase and its ligand, BDNF, have an essential role in certain forms of synaptic plasticity. Results provide evidence that TrkB mediates hippocampal plasticity via recruitment of PLCgamma, and by subsequent phosphorylation of CaMKIV (3). Also, TrkB has been found to be essential to the development of GABAergic neurons and regulates synapse formation in addition to its role in the development of axon terminals (4). |
MAPK signaling pathway
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Western blot analysis on rat brain lysates using anti-Phospho-TrkB (pY817), 1:10,000 dilution. Lysates were either (A) untreated or (B) treated with AP.