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Home Antibody All anti-NRAS antibodies

Anti-NRAS Antibody Y131

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300481
  • Rabbit Monoclonal Antibody against NRAS (Clone Y131)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400901) , 20ug
100ul 325 3-7 Days
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WB(1)
IF(1)
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Also for NRAS (NM_002524)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the effector region of human Ras was used as an immunogen. Predicted to react with other Ras family members and cross-react with most species based on sequence homology.
Clone NameY131 IsotypeIgG
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:1000 - 1:10000; ICC/IF: 1:50
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,IHC or IP.

Reference Data

Target NameHomo sapiens neuroblastoma RAS viral (v-ras) oncogene homolog (NRAS)
Alternative NameALPS4; CMNS; N-ras; NCMS; NRAS1; NS6
Database LinkNP_002515
FunctionRas, a signal transducer, was first characterized as the transforming genes of Harvey & Kristen sarcoma virus (1). The Ras family (H-Ras, N-Ras, and K-Ras) regulates cell growth, differentiation and apoptosis (2). Switching from an active or resting state, Ras can either bind GTP or GDP respectively. In the triphosphate conformation, Ras will interact with GTPase activating protein (GAP) to increase its activity (3). Mutations in any of the three isoforms can convert these proteins into active oncogenes. Additionally, Ras mutations are found in 30 % of all human cancer (4).
Related Pathway
EGFR1 Signaling Pathway
Hemostasis
MAPK signaling pathway
Melanogenesis

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WB Image
Western blot - Ras antibody [Y131]; Anti-Ras antibody [Y131] at 1/500 dilution + MCF7 cell lysate.Predicted band size : 21 kDa.Observed band size : 21 kDa.
IF Image
Immunocytochemistry/ Immunofluorescence - Ras antibody [Y131]; Immunofluorescent staining of HeLa cells using TA300481 at 1/50 dilution.

 

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