NR1H4 is a ligand-activated transcription factor, and is receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. It represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. NR1H4 activates the intestinal bile acid-binding protein (IBABP), and the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus (1).
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