Anti-NR1H4 Antibody, EPR5721

Also for NR1H4 (NM_001206977)

Gene Name	Homo sapiens nuclear receptor subfamily 1, group H, member 4 (NR1H4), transcript variant 6
Synonyms:	BAR; FXR; HRR-1; HRR1; RIP14
Immunogen	A synthetic peptide corresponding to residues in human NR1H4 was used as an immunogen.
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Clone Name	EPR5721	Isotype
Species Reactivity	Human, Mouse, Rat	Concentration
Purification	(Protein A or G Sepharose)
Guaranteed Application *	WB	Suggested Dilutions	WB: 1:1,000 - 10,000; IHC 1:100 - 250; FC: 1:100 - 500;
Background	NR1H4 is a ligand-activated transcription factor, and is receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. It represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. NR1H4 activates the intestinal bile acid-binding protein (IBABP), and the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus (1).
Related Pathway

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WB Image

Western blot analysis on (A) fetal liver, (B) HepG2, (C) HeLa, and (D) 293T cell lysates using anti-NR1H4 RabMAb.

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Anti-NR1H4 Antibody EPR5721

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