Home Antibody All anti-NPTX2 antibodies
Also for NPTX2 (NM_002523)
|NPTX2 antibody was raised against a 16 amino acid peptide near the center of the human NPTX2.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens neuronal pentraxin II (NPTX2)|
|NARP; NP-II; NP2|
|Neuronal pentraxin (NPTX) 2 was initially identified as a member of the pentraxin family having high homology to NPTX1. Unlike NPTX1 however, NPTX2 is expressed in testes, pancreas, liver, heart, skeletal muscle as well as brain. NPTX2 possesses the lectin properties common to the pentraxin family, promotes neurite outgrowth, and is rapidly regulated by neuronal activity. NPTX1 and NPTX2 form heterocomplexes that contribute to both activity-independent and –dependent excitatory synaptogenesis. Recently, NPTX2 has been found to be highly upregulated in Parkinsonian substantia nigra and localizes to Lewy bodies and Lewy neurites in sporadic Parkinson’s disease (PD), suggesting that it is involved in the pathway dysregulation that underlies PD. This NPTX2 antibody is predicted to be specific to NPTX2 and not recognize NPTX1.|
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Western blot analysis of NPTX2 in mouse brain tissue lysate with NPTX2 antibody at (A) 0.5 and (B) 1 ug/ml.
Immunohistochemistry of NPTX2 in human brain with NPTX2 antibody at 5 ug/ml.