Nephrin (NPHS1) is an immunoglobulin family adhesion protein expressed in visceral glomerular epithelial cells (podocytes), where it is targeted to the intercellular slit diaphragm of mature foot processes (1). It is an essential component of the kidney filtration barrier, and mutations in the nephrin gene are associated with congenital nephrotic syndrome (2). Nephrin binds via phosphorylated tyrosine residues in the intracellular domain to SH2 domain-containing signaling molecules such as Nck (3).
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A. Western blot analysis on (A) HEK293T cells transfected with wild type CD 16/7 Nephrin (B) HEK293T cells transfected with active tyrosine kinase (vSrc) (C) HEK293T cells transfected with Nephrin mutated at Tyr1217 and vSrc using Phospho Nephrin (pY1176/1193) RabMAb .
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