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Anti-NPC1 Antibody EPR5209


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA310727 Rabbit Monoclonal antibody against NPC1 100ul $325 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues at the C-terminus of human NPC1 was used as an immunogen.
Clone NameEPR5209 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, Assay, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:50 - 1:100; ICC/IF: 1:100 - 1:250
Predicted MW Explanation 142 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens Niemann-Pick disease, type C1 (NPC1)
Alternative NameNPC
Database LinkNP_000262
Entrez Gene 4864 Human
Entrez Gene 18145 Mouse
Entrez Gene 266732 Rat
FunctionNPC1 is a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this protein cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by overaccumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments (1).
Related PathwayTransmembraneDruggable Genome Lysosome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Niemann Pick C1 antibody; All lanes : Anti-Niemann Pick C1 antibodyat 1/1000 dilution.Lane 1 : 3T3 L1 cell lysate.Lane 2 : L6 cell lysate.Lane 3 : HepG2 cell lysate .Lane 4 : THP1 cell lysate .Lane 5 : 293T cell lysate.Lane 6 : PC3 cell lysate .Lane 7 : Rat liver lysate .Lane 8 : Rat brain lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP conjugated antibody at 1:2000.Predicted band size : 142 kDa.Observed band size : 180 kDa .

Assay Image
Other-Anti-Niemann Pick C1 antibody [EPR5209](TA310727); Equilibrium disassociation constant (KD)..

IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Niemann Pick C1 antibody [EPR5209]; Immunohistochemical analysis of paraffin embedded Human kidney tissue labelling Niemann Pick C1 with TA310727 at 1/50.


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