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Home Antibody All anti-NPC1 antibodies

Anti-NPC1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306785
  • Rabbit Polyclonal NPC1 Antibody
100ug $325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenNPC1 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human NPC1.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens Niemann-Pick disease, type C1 (NPC1)
Alternative NameNPC
Database LinkNP_000262
FunctionMutations in the Niemann-Pick disease type C1 (NPC1) gene result in a fatal progressive neurodegenerative disorder characterized by an abnormal sequestration of lipids including cholesterol and glycosphingolipids. The NPC1 protein is a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. NPC1, in addition to FTO, MC4R, and PTER has recently been shown to be a new risk loci for early-onset and morbid adult obesity in European populations. This anti-NPC1 antibody will not cross-react to NPC2, another gene whose defects also result in Niemann-Pick type C disease.
Related Pathway

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WB Image
Western blot analysis of NPC1 in human kidney tissue lysate with NPC1 antibody at 1 ug/ml.
IHC Image
Immunohistochemistry of NPC1 in mouse kidney tissue with NPC1 antibody at 2.5 ug/ml.

 

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